Vinyl Chloride Exposure Liver

Vinyl chloride exposure is associated with an increased risk of a rare form of liver cancer hepatic angiosarcoma as well as brain and lung cancers lymphoma and leukemia.

Vinyl chloride exposure liver.

Angiosarcoma and hepatocellular carcinoma. Iarc monographs on the evaluation of carcinogenic risks to humans vol 97. The causal link between vinyl chloride exposure and lung cancer must be further investigated. Meta analysis of studies of occupational exposure to vinyl chloride in relation to cancer mortality.

Cases of liver angiosarcoma have been reported among individuals employed in pvc fabrication facilities and an epidemiological study has demonstrated a significant association between exposure to pvc dust and the risk of lung cancer mortality. Breathing vinyl chloride for long periods of time can result in permanent liver damage immune reactions nerve damage and liver cancer. Shipped as a liquefied compressed gas. How can exposures be reduced.

Liver damage is the most serious health risk of vinyl chloride. Portal hypertension liver fibrosis and angiosarcoma of the liver asl have been reported among workers exposed to vinyl chloride monomer vcm since the 1970s. The evidence for a carcinogenic risk has been extended to jobs associated with poly vinyl chloride exposure. However the data on which this conclusion is based is incomplete.

Liver side effects of vinyl chloride. This substance has been found in at least 616 of the 1 662 national priority list sites identified by the environmental protection agency epa. It also has other toxic effects on the liver and it has recently been suggested that exposure to vinyl chloride also causes hepatocellular carcinoma. In 2007 the international agency for research on cancer established the association of vcm with hepatocellular carcinoma hcc though only on the basis of the few cases available.

In 1949 a russian publication discussed the finding that vinyl chloride caused liver injury among workers. The evidence of a causal link between vinyl chloride exposure and liver cancer is anyhow confirmed. There is inadequate ascertainment of unequivocal diagnoses. Vinyl chloride is also known to cause fibrosis scarring of the liver which is a risk factor for hepatocellular carcinoma.

Occupational safety health administration provides information about exposure limits to vinyl chloride. Vinyl chloride monomer is a known cause of angiosarcoma of the liver. Chloroethene chloroethylene ethylene monochloride monochloroethene monochloroethylene vc vcm vinyl chloride monomer vcm colorless gas or liquid below 7 f with a pleasant odor at high concentrations. 1 3 butadiene ethylene oxide and vinyl halides vinyl fluoride vinyl chloride and vinyl bromide.